​L-leucine

L-leucine is an essential branched-chain amino acid and the fourth most prevalent amino acid in muscle tissue. In addition to its structural role for proteins, leucine is also a signaling molecule. Aging is consistently associated with loss of muscle mass and increased fat mass. Leucine, along with exercise, is important protection against both muscle loss and fat gain¹. Leucine is a well-known activator of the mammalian target of rapamycin (mTOR), a key regulator of metabolism that signals the body to make proteins for muscle, controls energy (food) intake, and regulates glucose metabolism². Therefore, adequate intake of leucine may be important for avoiding age-associated muscle loss and glucose dysregulation. Some people obtain leucine from branched-chain amino acid (BCAA) supplements. However, that may not be the best strategy. BCAAs include leucine, isoleucine, and valine. Although all three BCAAs are essential amino acids, excessive valine has been shown to cause glucose intolerance, and too much valine may negate the benefits of L-leucine or even have negative effects³. Daily’s L-leucine is pure L-leucine derived from plant sources and is the highest quality leucine available. People who believe they can benefit from an L-leucine supplement should take at least two Daily’s L-leucine tablets per day for a 1000 mg dose combined with a daily exercise program that includes both endurance and resistance exercise¹.

References

1.James W. Daily and Sunmin Park. (2022) Sarcopenia Is a Cause and Consequence of Metabolic Dysregulation in Aging Humans: Effects of Gut Dysbiosis, Glucose Dysregulation, Diet and Lifestyle. Cells; 11(3): 338. doi: 10.3390/cells11030338

2.Pedroso, JAB et al. (2015) Reviewing the effects of L-leucine supplementation in the regulation of food intake, energy balance, and glucose homeostasis. Nutrients 7:3914-3937.

3.Bishop CA et al. (2022) Detrimental effects of branched-chain amino acids in glucose tolerance can be attributed to valine induced glucotoxicity in skeletal muscle. Nutrition and Diabetes 12:20. doi: 10.1038/s41387-022-00200-8.

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